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Научная и техническая литература
Studies on Andrographolide from Andrographis paniculata

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Andrographolide is the main diterpenoid lactone contained in the leaves of Andrographis paniculata. This bioactive component has multifunctional medicinal properties such as activity against fever, dysentery, diarrhoea, inflammation, cancer and sore throat as well as immune disorder. No solvent is ideal for the extraction of Andrographolide, however we can consider 60% methanol for the model development. Cancer is the largest single cause of death in both men and women, claiming over 6 million each year in the world. CML accounts for about 20% cases of adult and childhood leukemia. Andrographolide acts by targeting the tyrosine kinase activity of BCR-ABL which represents a very promising therapeutic strategy in chronic myeloid leukemia (CMML). In the present study, we focused on amplifying the ABL kinase domain sequence and b2a2 junction domain sequence and tried to find out the sequence difference between normal K562 cells and AR-K562 cells .for this we developed resistant cell lines against Andrographolide by gradual increase in the in the concentration of Andrographolide (1nm to 1um), the morphological features were studied in phase contrast microscopy.

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The Future of Remedies in Europe

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Remedies lie at the heart of European legal systems. They both reflect and shape the balance of power between states and individuals and between state and supranational institutions. These profound political implications can be better understood by thinking about the functional roles and institutional histories of remedies. These implications,roles and histories are considered in this volume of challenging and original essays on remedial systems in Europe. This book explores the lively and often controversial dialogues between courts, national and supranational, on remedies. In so doing, it addresses the adequacy of these dialogues in the light of perceived systemic goals, both in an overall institutional sense and as regards specific sectoral objectives or institutional actors’ aspirations. In particular, the book looks at the way in which remedies in the EC legal order interact with those in other legal orders such as the Council of Europe and private international law. It also identifies problems of interaction between different Council of Europe mechanisms under the Convention on Human Rights and the Social Charter. The book also examines the contribution of courts to remedial systems by considering other methods of formulating and redressing claims. Contributors: Claire Kilpatrick, Takis Tridimas, Leo Flynn, Antonio Lo Faro, Carol Harlow, Steve Weatherill, Bernard Ryan, Miguel Poiares Maduro, Henry G.Schermers, Angela Ward, Paul Beaumont, Robin White, Phil Syrpis, Tonia Novitz, Richard Rawlings.

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Membrane Contactors: Fundamentals, Applications and Potentialities

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Russia Engages the World 1453–1825

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Russia Engages the World 1453–1825

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Lead Toxicity

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Lead Toxicity

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Биотический кризис рубежа палеозоя и мезозоя Европейской России

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Крупнейшему в истории Земли вымиранию биоты на рубеже палеозоя и мезозоя посвящено большое количество исследований. Установлено несомненное влияние на этот процесс глобальных изменений климата. Отражение этого кризиса на юго-востоке Восточно-Европейской платформы рассматривается в данной работе. Не вдаваясь в полемику об основных причинах климатических событий, авторы в деталях проследили геоэкологические изменения и связанное с ними развитие биоты на юго-востоке Волго-Уральской антеклизы и Южного Предуралья в предкризисный, кризисный и реабилитационный периоды. На этой территории полно развиты отложения перми и триаса, что позволило провести реконструкцию палеоландшафтов и изменений биоты с большой детальностью. Подобное описание развития конкретного региона в кризисный период на рубеже палеозоя и мезозоя проведено впервые. Данная работа может быть использована как учебное пособие для геологических вузов при изучении континентальных аридных формаций, а также при решении практических вопросов палеогеографии континентов при аридном климате.

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Our Last Backpack – A Memoir

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Our Last Backpack – A Memoir

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Land Use and the States

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Land Use and the States

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Schmitt: ?neurosciences? Resear Symp Summ: An Anth  Of Work Session Repo From Resea Prog Bull

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Schmitt: ?neurosciences? Resear Symp Summ: An Anth Of Work Session Repo From Resea Prog Bull

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Ottensmann: Working With Lotus ?agenda? (pr Only)

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Ottensmann: Working With Lotus ?agenda? (pr Only)

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